History of Fucoidan – 900 Studies And Counting

Fucoidan is an element found in brown seaweed. As a sulfated polysaccharide, it’s commonly found in seaweeds like limu moui or kombu.

A studied nutritional supplement alongside other ingredients like flax seed and lutein, Fucoidan is of significant note for its many benefits to several body systems.

This web site is a singular source for all science, news and announcements on this burgeoning supplement found in the earth’s extraordinary ocean. With over 900 studies found on Pub Med and interest from the pharmaceutical industry, Fucoidan is one of the most intriguing and powerful supplements on the market.

Here at fucoidanfacts.com, find all the facts you need to begin supplementing your life with the complete health benefits of Fucoidan.

Beneath The Surface – Science Meets Tradition

Coastal communities have been known to have low incidences of disease and increased longevity. Specifically, the Japanese people, with their diet of soy, fish and variety of sea plants, including brown seaweed, have very low rates of disease. Continuously the southern area of Japan has the lowest mortality rates for all types of cancer.

In addition, the people on the island of Tonga have revered the brown seaweed plant, limu moui for thousands of years. Interestingly, limu moui has been found to have the richest concentration of Fucoidan among brown seaweeds. The seaweed has been used traditionally in various forms (tea, poultices, rubs, etc.) throughout Tongan generations.

Scientists have strengthened the link between this kind of diet and health through countless studies and research.

Revealing The Research On Fucoidan – The Marine Bioactive

Among the countless studies on Fucoidan, researchers have found that the marine bioactive has a very complete profile. Studies have been performed in the following areas:
APOPTOSIS(1 – 4) is a process of cell elimination.  The body programs each cell’s natural progression and eliminates harmful cells.  Fucoidan has been shown to induce this process, which is helpful for example, in tissues affected with disease like tumor activity.

1.  Maruyama H, Tamauchi H, Hashimoto M, Nakano T.  2003 May-Jun; 17(3): 245-9
Antitumor activity and immune response of Mekabu fucoidan
Quote from the abstract: “We showed that fucoidan, extracted from dietary seaweed, could inhibit tumor growth.”

2. Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H. 1993 Nov-Dec; 13(6A): 2045-52

Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan

Quote from study conclusion:  “These results suggest that the antitumor activity of fucoidan is related to the enhancement of immune responses. The present results indicate that fucoidan may open new perspectives in cancer chemotherapy.”

3. Haneji K, Matsuda T, Tomita M, Kawakami H, Oshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N. 2005;52(2): 189-201  Fucoidan extracted from brown seaweed induces apoptosis of audlt T-cell leukemia cells

Quote from study conclusion:  “Our results indicate that fucoidan is a potentially useful therapeutic agent for patients with ATL.”

4.  Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Slavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand  P, Roussakis C. 1996 May-Jun; 16(3A); 1213-8 Antitumor effects of fucoidan extracted from brown seaweed

Quote from study conclusion:  “exhibits inhibitory effect both in vitro and in vivo and a very potent antitumor agent.”


OTHER IMMUNE SYSTEM SUPPORT(5-6) through Fucoidan comes in the form of modulation, or the ability to balance cellular activity (inhibit or stimulate).  The cells communicate to either boost (chronic fatigue, common cold, etc.) or suppress (rheumatoid arthritis, lupus, etc.) through proteins and polysaccharides. As Fucoidan includes fucose, a necessary saccharide, it streamlines the cell communication process when the body is jeopardized.


5.  Zapopozhets TS, Besednova NN, Loenko LuN.  1995 Feb;40(2): 9-13

Antibacterial and immunomodulating activity of fucoidan

6.  Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB.  1999 Nov;6(5): 335-40

Antiviral properties of fucoidan



CELL REGENERATION(7) has been studied as Fucoidan may support the gathering of stem cells so they are able to replace dead cells.  This leads to interest in tissue and organ revival.

7.  Frenette PS, Weiss L.  2000 Oct 1;96(7):  2460-8

Using fucoidan for stem cells mobilization Study concludes that the use of sulfated glycans including fucoidan “represents a powerful, novel method for rapid mobilization of long-term-repopulating stem cells.”


CIRCULATORY SYSTEM(8-10) research on Fucoidan has shown its support of health functioning of blood and cardiac processes.  Another study shows Fucoidan slowing the glucose absorption rate.

8.  McCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB. 1992 Apr 30;184(2):  773-81

Fucoidan is a non-antioagulant inhibitor of intimal hyperplasia

9.  Soeda S, Sakaguchi S, Shimeno H, Nagamatsu A. 1992 Apr 15;43(8): 1853-8

Anticoagulant activities of highly sulfated fucoidan


CHOLESTEROL MAINTENANCE(10) in Fucoidan research suggests the marine bioactive can help maintain LDLs and HDLs in the ideal range.


10. Murata M, Ishihara K, Saito H.  1998 May; 236-8648

Hepatic fatty acid oxidation enzyme activities are stimulated



ANTIOXIDANT/DETOXIFICATION(11) function is crucial to complete health.  Free radical damage is well known and the beneficial effects of antioxidants in supplements have been well received by consumers.  Fucoidan continues to be studied for its antioxidant ability.

11.  Ruperez P, Ahrazem O, Leal JA.  2002 Feb 13;50(4): 840-5

Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed

The conclusion:  “Sulfated polysaccharides from edible seaweeds potentially could be used as natural antioxidants.”



WEIGHT MANAGEMENT(12-13) benefits from Fucoidan are found in the marine bioactive’s ability to inhibit the adipogenesis process – or the creation of new fat cells.  In addition, Fucoidan may increase chemical levels to enhance the breakdown of fat cells.

12. Yokota T, Nagashima M, Ghazizadeh M, Kawanami O.  2009 Apr 10;84(15-16): 523-9

Increased effect of fucoidan on lipoprotein lipase secretion in adipocytes

13. Kim MJ, Chang UJ, Lee JS 2009 Sep-Oct;11(5): 557-62

Inhibitory effects of fucoidan in 3T3-L1 adipocyte differentiation

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease



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